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2078: On a distant mining planet ravaged by a decade of war, scientists have created the perfect weapon: a blade-wielding, self-replicating race of killing devices know as Screamers, designed for one purpose only – to hunt down and destroy all enemy life forms. But man’s greatest weapon has continued to evolve without any human guidance, and now it has devised a new mission: to obliterate all life.

Colonel Hendricksson (Peter Weller) is commander of a handful of Alliance soldiers still alive on Sirius 6B. Betrayed by his own political leaders and disgusted by the atrocities of this ever-ending war, Hendricksson decides he must negotiate a separate peace with the New Economic Bloc’s decimated forces. But to do so he will have to cross a treacherous wasteland where the deadliest threat comes from the very weapons he helped to create – the Screamers.

With Ace (Andy Lauer), a young trooper, to accompany him, Hendricksson sets out on foot for the enemy bunker which lies across a wasteland poisoned by radioactivity and guarded by deadly Screamers. Miraculously the Colonel and Ace find someone who has managed to survive in the middle of this desolate killing ground – a small boy, David (Michael Caloz), lost, alone and clutching a filthy teddy bear.

Taking David with them, the two soldiers forge ahead to the New Economic Bloc bunker, only to discover that the Screamers have beaten them there. Just three of the enemy survived the carnage: Becker (Roy Dupuis) a menacing soldier with a hidden agenda; Ross (Charles Powell) a trooper close to breaking point and Jessica (Jennifer Rubin), a beautiful, tough black-market trader.

One safe haven remains for friends and foe alike: the Alliance headquarters, but to reach it they will all have to fight their way through an army of Screamers who have grown infinitely more cunning in their drive to wipe out every human on the planet.